Indy $500: Race to the shops

Longevity of Indy mutant Drosophila not attributable to Indy mutation.

In their recent study in PNAS, Neretti et al. (1) identify mitochondrial defects in male Drosophila melanogaster that are heterozygous for the mutation Indy206. This allele lowers the expression of Indy, which encodes a Krebs cycle intermediate transporter and was previously proposed to increase adult f ly lifespan (2). The authors propose an interesting model in which mitochondria work at lowe...

Indy User's Manual (v1.8)

What is "Race-To-The-Bottom" Effect On FDI Inflow?

Indy Mutations and Drosophila Longevity

Decreased expression of the fly and worm Indy genes extends longevity. The fly Indy gene and its mammalian homolog are transporters of Krebs cycle intermediates, with the highest rate of uptake for citrate. Cytosolic citrate has a role in energy regulation by affecting fatty acid synthesis and glycolysis. Fly, worm, and mice Indy gene homologs are predominantly expressed in places important for...

The Role of INDY in Metabolic Regulation

Reduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc 3a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by ...